Auditorio CAB. Seminario: Long Non Coding RNAs (R)evolution

Ponente: Cedric Notredame, Centro de Regulación Genómica (CRG) de Barcelona

22 de marzo de 2013, 12:00h

Auditorio Centro de Astrobiologia (CSIC-INTA)

La conferencia se podrá seguir en directo a través del enlace rtsp://roa.cti.csic.es/cab.sdp

Instituto Nacional de Técnica Aeroespacial
Ctra de Ajalvir, km 4
28850 Torrejón de Ardoz, Madrid

Para facilitar el acceso a recinto del INTA es necesario solicitarlo previamente al correo electrónico gerencia@cab.inta-csic.es

Resumen: The recent report of a large number of new long non-coding RNA genes in human (known as lincRNAS or lncRNA) has been one of the main discoveries of these last years. According to various estimates and extrapolations, there could be anywhere between 15.000 and 50.000 such genes in the human genome, and a comparable number in most mammals. Attention is now shifting towards other species (model or not) in order to enable comparative genomics approaches. I will present some of the methods recently developed within our group for the systematic evolutionary profiling of non-coding RNA across genomes, and their subsequent analysis through multiple sequence alignment modeling. I will then develop some of our recent work on the comparative analysis done between human and various mammals such as cow, pig and mouse. All tools presented during the talk are available, as open-source packages and online resources, from www.tcoffee.org.

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